April 22, 2025 Edward Twomey

How Brain Temperature Modulates Ion Channel Activity

We found that the principal neurotransmitter receptors in the brain are more active at healthy/phyisological brain temperature (37 ˚C) and are even more active in feverish conditions! This has implications for drug design studies against these receptors, and also points to how variations in brain temperature due to brain injury, for example, can directly alter molecular function. Read more below!

 

Press release from Hopkins: https://www.hopkinsmedicine.org/news/newsroom/news-releases/2025/03/brain-channels-stopped-in-time-reveal-chemical-flow-that-enables-learning-and-thinking

 

Paper in Nature: https://www.nature.com/articles/s41586-025-08770-0