Regulatory subunits tightly control the function of glutamate receptors, which enables our brains to tune responses to the neurotransmitter glutamate. The structural features of how this occurs were unknown, which is a major barrier in understanding brain function as well as an obstacle to therapeutic development. We used a technology called cryo-electron microscopy or cryo-EM to decipher the molecular features that enable glutamate receptors to be regulated. Read more in our preprint below!
https://www.biorxiv.org/content/10.1101/2023.11.28.569079v1