Twomey Lab
We are a structural biology lab that is interested in method development and in understanding how ion channels, and the macromolecular complexes that regulate them, function in health and disease. Primarily, we will be applying cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) to reconstruct the biochemical and molecular processes underlying these problems. We firmly believe that the most informative mechanistic insights into biology come from a deep understanding of the biological machines that govern them.
Selected Recent Publications
Carrillo, E., Montaño-Romero, A., Gonzalez, C.U., Turcu, A.L., Chen, S., Chen, H., Pan, H., Vázquez, S., Twomey, E.C., Jayaraman, V. “Memantine Inhibits Calcium-Permeable AMPA Receptors.” BioRxiv. 2024. PMID: 39005433. Preprint.
Hale, W.D., Montaño-Romero, A., Gonzalez, C.U., Jayaraman, V., Lau, A.Y., Huganir, R.L., Twomey, E.C. “Allosteric Competition and Inhibition in AMPA Receptors.” Nature Structural & Molecular Biology. 2024. PMID: 38834914.
Montaño-Romero, A., Bonin, C., Twomey, E.C. “C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules.” IUCrJ. 2024. PMID: 38096039.
Memantine Inhibits Calcium-Permeable AMPA Receptors
Mechanism of AMPA Receptor Inhibition
