Twomey Lab at Johns Hopkins University

Lab News

Jul 24

An expanded role for how the FDA-approved drug memantine functions.

With the Jayaraman Lab at UT Health Houston, we show that memantine inhibits calcium-permeable AMPA receptors (CP-AMPARs). This is significant... Read More

Dec 18

Congrats, Calli!

Calli Bonin, a star undergraduate in the lab, graduates from Hopkins! Congratulations, Calli!... Read More

Dec 15

First publication!

Our time-resolved cryo-EM platform, C-SPAM, has been published in IUCrJ! Congratulations, Alejandra and Calli! Link. ... Read More

Nov 28

How to tune neurotransmitter function

Regulatory subunits tightly control the function of glutamate receptors, which enables our brains to tune responses to the neurotransmitter glutamate.... Read More

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Selected Recent Publications

Carrillo, E., Montaño-Romero, A., Gonzalez, C.U., Turcu, A.L., Chen, S., Chen, H., Pan, H., Vázquez, S., Twomey, E.C., Jayaraman, V. “Memantine Inhibits Calcium-Permeable AMPA Receptors.” BioRxiv. 2024. PMID: 39005433. Preprint.

Hale, W.D., Montaño-Romero, A., Gonzalez, C.U., Jayaraman, V., Lau, A.Y., Huganir, R.L., Twomey, E.C. “Allosteric Competition and Inhibition in AMPA Receptors.” Nature Structural & Molecular Biology. 2024. PMID: 38834914.

Montaño-Romero, A., Bonin, C., Twomey, E.C. “C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules.” IUCrJ. 2024. PMID: 38096039.

Lab News

Selected Recent Publications

Memantine Inhibits Calcium-Permeable AMPA Receptors

Mechanism of AMPA Receptor Inhibition