Below is a list of publications. Please visit Google Scholar and PubMed for more up-to-date information. * denotes equal contribution.

At Hopkins:

  1. Twomey, E.C. “Aboard the ISS: intersubunit signaling revealed in the p97 ATPase.” Nature Structural & Molecular Biology, 28: 538-539 (2021). PMID: 34262182. Commentary.
  2. Montaño-Romero, A., Bonin, C., Twomey, E.C. “Time-Resolved Cryo-EM Specimen Preparation with Single Millisecond Precision.” BioRxiv. Preprint.


  1. Twomey, E.C., Yelshanskaya, M.V., Sobolevsky, A.I. “Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes.” Journal of General Physiology, Dec 12;151(12). PMID: 31615831.
  2. Twomey, E.C.*, Ji, Z.*, Wales, T.E., Bodnar, N.O., Ficarro, S.B., Marto, J.A., Engen, J.R., Rapoport, T.A. “Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.” Science, Aug 2;365(6452). pii: eaax1033. PMID: 31249135.
  3. Twomey, E.C., Yelshanskaya, M.V., Vassilevski, A.A., Sobolevsky, A.I. “Mechanisms of channel block in calcium-permeable AMPA receptors.” Neuron, 99: 956-968 (2018). PMID: 30122377. Featured as issue cover.
  4. Singh, A.K.*, McGoldrick, L.L.*, Twomey, E.C., Sobolevsky, A.I. “Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6.” Science Advances, 4: eaau6088 (2018). PMID: 30116787.
  5. Twomey, E.C., Sobolevsky, A.I. “Structural mechanisms of gating in ionotropic glutamate receptors.” Biochemistry, 57: 267-276 (2018). PMID: 29037031.
  6. McGoldrick, L.L.*, Singh, A.K.*, Saotome, K., Yelshanskaya, M.V., Twomey, E.C., Grassucci, R.A., Sobolevsky, A.I. “Opening of the human epithelial calcium channel TRPV6.” Nature, 553: 233-237 (2018). PMID: 29258289.
  7. Twomey, E.C., Yelshanskaya, M.V., Grassucci, R.A., Frank, J., Sobolevsky, A.I. “Channel opening and gating mechanism in AMPA-subtype glutamate receptors.” Nature, 549: 60-65 (2017). PMID: 28737760.
  8. Twomey, E.C., Yelshanskaya, M.V., Grassucci, R.A., Frank, J., Sobolevsky, A.I. “Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.” Neuron, 94: 569-580 (2017). PMID: 28472657.
  9. Twomey, E.C., Yelshanskaya, M.V., Grassucci, R.A., Frank, J., Sobolevsky, A.I. “Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.” Science, 353: 83-86 (2016). PMID: 27365450.
  10. Twomey, E.C., Cordasco, D.F., Kozuch, S.D., Wei, Y. “Substantial conformational change mediated by charge triad residues of death effector domain in protein-protein interactions.” PLoS ONE (2013). PMID: 24391764.
  11. Twomey, E.C., Cordasco, D. F., Wei, Y. “Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics.” Biochimica et Biophysica Acta – Proteins and Proteomics 1824, 1382-1393 (2012). PMID: 22820249.
  12. Twomey, E.C., Wei, Y. “High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.” Biochemical and Biophysical Research Communications 424, 141-146 (2012). PMID: 22732408.