Below is a list of publications. Please visit Google Scholar and PubMed for more up-to-date information. * denotes equal contribution.

At Hopkins:

  1. Twomey, E.C. “Aboard the ISS: intersubunit signaling revealed in the p97 ATPase.” Nature Structural & Molecular Biology, 28: 538-539 (2021). PMID: 34262182. Commentary.
  2. Montaño-Romero, A., Bonin, C., Twomey, E.C. “C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules.” IUCrJ. PMID: 38096039.
  3. Hale, W.D., Montaño-Romero, A., Gonzalez, C.U., Jayaraman, V., Lau, A.Y., Huganir, R.L., Twomey, E.C. “Allosteric Competition and Inhibition in AMPA Receptors.” BioRxiv. PMID: 38076818. Preprint.
  4. Hale, W.D.*, Montaño-Romero, A.*, Huganir, R.L., Twomey, E.C. “Structure of Transmembrane AMPA Receptor Regulatory Protein Subunit γ2.” BioRxiv. PMID: 38076787. Preprint.

Pre-Hopkins:

  1. Twomey, E.C., Yelshanskaya, M.V., Sobolevsky, A.I. “Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes.” Journal of General Physiology, Dec 12;151(12). PMID: 31615831.
  2. Twomey, E.C.*, Ji, Z.*, Wales, T.E., Bodnar, N.O., Ficarro, S.B., Marto, J.A., Engen, J.R., Rapoport, T.A. “Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.” Science, Aug 2;365(6452). pii: eaax1033. PMID: 31249135.
  3. Twomey, E.C., Yelshanskaya, M.V., Vassilevski, A.A., Sobolevsky, A.I. “Mechanisms of channel block in calcium-permeable AMPA receptors.” Neuron, 99: 956-968 (2018). PMID: 30122377. Featured as issue cover.
  4. Singh, A.K.*, McGoldrick, L.L.*, Twomey, E.C., Sobolevsky, A.I. “Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6.” Science Advances, 4: eaau6088 (2018). PMID: 30116787.
  5. Twomey, E.C., Sobolevsky, A.I. “Structural mechanisms of gating in ionotropic glutamate receptors.” Biochemistry, 57: 267-276 (2018). PMID: 29037031.
  6. McGoldrick, L.L.*, Singh, A.K.*, Saotome, K., Yelshanskaya, M.V., Twomey, E.C., Grassucci, R.A., Sobolevsky, A.I. “Opening of the human epithelial calcium channel TRPV6.” Nature, 553: 233-237 (2018). PMID: 29258289.
  7. Twomey, E.C., Yelshanskaya, M.V., Grassucci, R.A., Frank, J., Sobolevsky, A.I. “Channel opening and gating mechanism in AMPA-subtype glutamate receptors.” Nature, 549: 60-65 (2017). PMID: 28737760.
  8. Twomey, E.C., Yelshanskaya, M.V., Grassucci, R.A., Frank, J., Sobolevsky, A.I. “Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.” Neuron, 94: 569-580 (2017). PMID: 28472657.
  9. Twomey, E.C., Yelshanskaya, M.V., Grassucci, R.A., Frank, J., Sobolevsky, A.I. “Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.” Science, 353: 83-86 (2016). PMID: 27365450.
  10. Twomey, E.C., Cordasco, D.F., Kozuch, S.D., Wei, Y. “Substantial conformational change mediated by charge triad residues of death effector domain in protein-protein interactions.” PLoS ONE (2013). PMID: 24391764.
  11. Twomey, E.C., Cordasco, D. F., Wei, Y. “Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics.” Biochimica et Biophysica Acta – Proteins and Proteomics 1824, 1382-1393 (2012). PMID: 22820249.
  12. Twomey, E.C., Wei, Y. “High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.” Biochemical and Biophysical Research Communications 424, 141-146 (2012). PMID: 22732408.